Rotatin Rosuvastatin 10mg, 20mg Tablets
روٹائن
DESCRIPTION:https://luckasluck.click/rotatin-rosuvast…0mg-20mg-tablets/
( روز و واسٹائین ) ۱۰ ملی گرام، ۲۰ ملی گرام گولیاں
Rotatin (Rosuvastatin), a synthetic lipid-lowering egent for oral administration, Rosuvastatin calcium is bis[(E)-7(4-(4-fluorophenyl)- 6isopropyl-2-(methyl (methylsulfonyl) amino) pyrimidin-5-yl)93R.5S)- 3,5-dihydroxyhept-6-enoic acid) calcium salt. The molecular formula for rosuvastatin calcium is (C22H27FN3O6S)
CLINICAL PHARMACOLOGY:
Mechanism of Action:
Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that convert 3-hydroxy-3-methyl glutryl coenzyme A to mevalonate, a precursor for cholesterol The primary site of action was rosuvastatin is in liver, the target organ for cholesterol lowening Rosuvastatin increase the number of hepatic LDL receptors on the cell-surface, enhancing uptake and catabolism of LDL and it inhibits the hepatic synthesis of VLDL therapy reducing the total number has LDL particles.
Pediatric Patients 10 to 17 years of age with Heterozygous familial Hypercholesterolemia are
Primary Dysbetalipoproteinemia (Type III Hyperlipoproteinemia)
DOSAGE AND ADMINISTRATION:
Also dose range for Rotatin (Rosuvastatin) is 5mg and 40mg orally one
daily.
CONTRAINDICATIONS:
Rosuvastatin is contraindicated
persistent elevations of serum transaminases and any serum transamirmses elevation exceeding the upper limit of normal.
In patients with myopathy In patients receiving concomitant cyclosponne
Concomitant use of protease inhibitors in HIV patients
ADVERSE REACTIONS:
Rosuvastatins generally well tolerated Adverse reactions have usually been mild and transient
Headache, dizziness, constipation, nausea, abdominal pain
Pruritus, rash was urticaria
Rare:
Hypersensitivity reactions including angioderma, myopathy
rhabdornyolysis, pancreatitis
PRECAUTIONS:
Rosuvastatin should be prescribed with caution in patients with predisposing factors for myopathy/rhabdomyolysis Such factors include
Antacid:
The risk of skeletal muscle effects may be enhanced when rosuvastatin or used in combination with niacin, a reduction in
OVERDOSAGE:
There is no specific treatment in the event of overdose the event was overdose, the patient should be treated symptomatically and supportive measures instituted as required Liver function.
استعمال دواڈاکٹر کی ہدایت کے مطابق استعمال کریں۔
ہدایات دوا کو دھوپ اور سی سے بچائیں۔ بچوں کی پہنچ سے دور رکھیں۔ ۳۰ ڈگری سینٹی گریڈ سے کم درجہ حرارت پر محفوظ کریں
The not pass was others. It may harm them, even if their symptoms are the same as youns > any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmac.
Drug Category:
All following single dose administration of meloxicam, mean maximum plasma concentrations achieved within 2 hours for the suspension and within 5-6 hours with solid oral dosage forms (tablets)Once daily dosing leads of drug plasma concentrations with a relatively small peak-trough fluctuation in the range of 0.4-1.0 µg/ml for 7.5 mg doses and 0.8-2.0 µg/ml for 15 mg dossa, respectively (Cmin and Cmax at steady state, respectively). Meloxicam penetrates into synovial fluid to give concentrations approximately half of those in plasma.
Also of pain and inflarnymation in juvenile idiopathic arthritis and other musculoskeletal disorders.
unusual bruising or bleeding, chest pain, palpitations, fast heartbeat, swelling in extremities, blood in urine/stool/mouth/vomitus, acute fatigue, skin rash, itching, blister, lever, changes in hearing, ringing in eans,
Contraindicated or not recommended.
Pregnant patients should not take NSAIDs during last trimester of pregnancy.
The active peptic ulcer, GI bleeding, aspirin/anti-inflammatory to induced allergy, severa hepatic or renal failure, severe CHF, active inflammatory.
bowel disease, cerebrovascular bleeding, bleeding disorder, Treatment of pain after CABG
Congestive heart failure, liver cirrhosis, nephrotic syndrome, ranal
failure, hypovolemia, Gi upset, hypertension, ischaemic heart disease, peripheral arterial disease, cerebrovascular disease, other cardiovascular risk factors. Elderly Interactions:
Anticoagulants, lithium, IUDs, methotrexate, cholestyramine, diuretics, cyclosporin, antihypertensives, thrombolytics, other NSAIDS. tacrolinius, antiplatelets, SSRIs, corticosteroids.
Karlox 7.5mg tablets: Pick of 10’s Karlox 15mg tablets: Pack of 10’s.
خوراک ڈاکٹر کی ہدایت کے مطابق استعمال کریں۔
ہدایات دور کو کمرے کے درجہ حرارت (1500 سے 25 ) پر رکھیں۔ روشنی، دھوپ اورنگی سے بچائیں۔ بچوں کی بھی ہے اور رگیں ۔
صرف رجسٹر ڈ ڈاکٹر کے نسخہ پر فر وخت کریں۔
Manufactured by:
Plot No. 01, Street No. SS-3, National Industrial Zone Rawat Rawalpindi-Pakistan.