MONTICEL Tablets

Monticel tablets and sachet contains Montelukast sodium which is a leukotriene receptor antagonist that blocks substances called leukotriene and helps to relieve the symptoms of asthma. The structural formula is as follow.

QUALITATIVE & QUANTITATIVE:

COMPOSITION:

Each chewable tablet contains:

Montelukast (as Sodium)… 5mg Product complies USP specifications.

Each film coated tablet contains: Montelukast (as Sodium)… 10mg

Product complies USP specifications.

Each sachet contains: Montelukast (as Sodium)… 4mg

Product complies BP specifications.

INDICATION OF USE:

MECHANISM OF ACTION:

Cytochrome P450 2C8 is the major enzyme in the metabolism of Montelukast.. By blocking leukotriene, Montelukast improves asthma symptoms and helps control asthma.

PHARMACOKINETICS:

After organization of the 10-mg film covered tablet to abstained grown-ups, the mean pinnacle

مونٹی سیل گولیاں اور ساشے (مونٹیلو کاسٹ سوڈیم)

The mean oral bioavailability is Cmax is nearly 2-fold greater than in adults receiving a 10 mg tablet. . The co-organization of the oral granule definition with fruit purée didn’t affect the pharmacokinetics of montelukast.

Distribution:

Montelukast is more than 99% bound to plasma proteins. The steady-state volume of distribution of Monticel averages 8-11 liters.

Metabolism:

Cytochrome P450 2C8 is the significant catalyst in the digestion of Montelukast.

Elimination:

Also no dosage adjustment is necessary for the elderly or mild to moderate hepatic insufficiency .Concentrates on in patients with renal debilitation have not been embraced.

CONTRA-INDICATION:

INTERACTION:

Montelukast focus was diminished roughly 40% no subjects with co-organization of phenobarbital, phenytoin, and rifampicin.

For adults and adolescents 15 years of age and older: one 10-mg film coated tablet to be swallowed with water.
For pediatric patients 6 to 14 years of age: one 5- mg chewable tablet to be chewed before swallowing.
For pediatric patients 6 months to 5 years of age one 4mg sachet. Try not to open the sachet until prepared to utilize However, your child may take liquids after swallowing Monticel tablet or sachet contents. Monticel can be taken without regard to the timing of food intake.
ADVERSE EFFECTS:
In clinical studies with Montelukast, the most commonly reported side effects (may affect up to 1 in 10 people) were: Diarrhea, hyperactivity, asthma, scaly and itchy skin rash, abdominal pain, headache, thirst, dizziness, drowsiness, pins and dry mouth, indigestion, bruising, itching or muscle pain, muscle cramps. . bedwetting in youngsters, shortcoming/sluggishness, feeling unwell, enlarging.
STORAGE & INSTRUCTION: Store below 30°CProtect from light, moisture & excessive heat. Keep all medicines out of the reach of children.Monticel 5mg chewable table 10mg film coated tablet are available in Alu-Alu blister in pack of 14s cach.
ہدایات

۳۰ گرمی سے کم درجہ حرارت پر رکھیں۔ روشنی انہی اور گرمی سے بچا ئیں ۔ تمام دوائیں بچوں کی وقتی سے دور رکھیں ۔ صرف مستندڈاکٹر کے لفہ پر ہی فروخت کی جائے۔

Axis.

Manufactured By:

Axis Pharmaceuticals

3-B, Value Addition City,

1.5 Km, Khurrianwala-Sahianwala Road Faisalabad-Pakistan Web: www.axispharmaceutical.com